云南大学化学科学与工程学院
专业：分析化学
主讲课程：分析化学、仪器分析实验。
团队：生物分析
电子信箱： lirong.sheng@ynu.edu.cn 受教育经历及工作经历： 2011和 2019 年先后获西南大学工学学士和理学博士学位；
2019-2022 年，北京大学 化学与分子工程学院 博士后；
2022-至今，云南大学 副教授。
研究领域和兴趣： 生物传感与治疗。
主要兴趣为：基于分子自组装与光学探针相结合的生物传感和细胞（细菌）功能调控。
论文、专著：
学术论文
1. Zhang, X.; Deng, G.; Chen, H. L.; Wang, Z. S.; Liu, J. Z.; Deng, B. X.; Chen, B. B.; Ye, M. J.; Ma, Y. X.; Zhou, C. H.; Qian, Y.; Chen, L. Q.; Zhen, S. J.; Wen, C.; Huang, C. Z.; Li, N.*; Xiao, W.*; Cao, Q.-e.; Ling, J.*; Li, R. S.*, Intelligent flexible nanospikes of covalent organic frameworks for eliminating biological and chemical threats in water. Matter 2026, 102755.
2. Zhang, R.; Yin, Q.; Li, D.; Yang, F.; Wang, X.; Chen, Y.; Yin, Q.; Wang, Z.; Wu, H.; Wang, L.; Chai, X.; Dong, Y.; Zhou, X.; Ling, J.; Li, R. S.*, Cao, Q., Aggregation-enhanced energy transfer: perovskite dye dual-emission ratiometric fluorescent sensing for antibiotic detection. Sensors and Actuators B: Chemical 2026, accepted.
3. Chai, X.; Lei, C.; Liu, H.; Yang, F.; Yin, D.; Bao, Z.; Liu, J.; Zhang, Q.; Shao, J.*; Li, R. S.*; Ling, J.*; Q.-E. Cao, Colorimetric/fluorescent/SERS/gas pressure four-modal sensing and killing of bacteria via enzyme-responsive aggregation of nanoparticles. Analytical Chemistry 2025, 97, 23108-23119.
4. Huang, Y.; Li, C.; Zhang, X.; Yu, T.; Liu, J.; Li, R. S.*; Ling, J.*; Q. Cao, Transformation of a covalent organic framework from dual pores to single pores and their different properties. Chemical Communications 2025, 61, 15250-15253.
5. Li, R. S.; Liu, J.; Wen, C.; Shi, Y.; Ling, J.; Cao, Q.; Wang, L.; Shi, H.*; Huang, C. Z. *; Li, N.*, Transformable nano-antibiotics for mechanotherapy and immune activation against drug-resistant Gram-negative bacteria. Science Advances 2023, 9 (34), eadg9601.
6. Li, R. S.; Wen, C.; Huang, C. Z.*; Li, N.*, Functional molecules and nano-materials for the Golgi apparatus-targeted imaging and therapy. TrAC Trends in Analytical Chemistry 2022, 156, 116714.
7. Li, R. S.; Liu, J.; Shi, H.*; Hu, P. P.; Wang, Y.; Gao, P. F.; Wang, J.; Jia, M.; Li, H.; Li, Y. F.; Mao, C.*; Li, N.*; Huang, C. Z.*, Transformable helical self-assembly for cancerous Golgi Apparatus disruption. Nano Letters 2021, 21 (19), 8455–8465.
8. Li, R. S.; Liu, J.; Yan, Y.; Su, C.; Lai, T.; Liao, Y.; Li, Y. F.; Li, N.*; Huang, C. Z.*, Aggregation-Enhanced Energy Transfer for Mitochondria-Targeted ATP Ratiometric Imaging in Living Cells. Analytical Chemistry 2021, 93 (34), 11878-11886.
9. Li, R. S.; Liu, J. H.; Yang, T.; Gao, P. F.; Wang, J.; Liu, H.; Zhen, S. J.; Li, Y. F.; Huang, C. Z.*, Carbon Quantum Dots–Europium(III) Energy Transfer Architecture Embedded in Electrospun Nanofibrous Membranes for Fingerprint Security and Document Counterspy. Analytical Chemistry 2019, 91 (17), 11185-11191.
10. Li, R. S.; Gao, P. F.; Zhang, H. Z.; Zheng, L. L.; Li, C. M.; Wang, J.*; Li, Y. F.; Liu, F.; Li, N.*; Huang, C. Z.*, Chiral nanoprobes for targeting and long-term imaging of the Golgi apparatus. Chemical Science 2017, 8 (10), 6829–6835.
11. Li, R. S.; Yuan, B.; Liu, J. H.; Liu, M. L.; Gao, P. F.; Li, Y. F.; Li, M.; Huang, C. Z.*, Boron and nitrogen co-doped single-layered graphene quantum dots: a high-affinity platform for visualizing the dynamic invasion of HIV DNA into living cells through fluorescence resonance energy transfer. Journal of Materials Chemistry B 2017, 5 (44), 8719-8724.
12. Li, R. S.; Zhang, H. Z.; Ling, J.; Huang, C. Z.; Wang, J.*, Plasmonic platforms for colorimetric sensing of cysteine. Applied Spectroscopy Reviews 2016, 51 (2), 129-147.
13. Li, R. S.; Liu, H.; Chen, B. B.; Zhang, H. Z.; Huang, C. Z.; Wang, J.*, Stable gold nanoparticles as a novel peroxidase mimic for colorimetric detection of cysteine. Analytical Methods 2016, 8 (11), 2494-2501.
14. 李荣生, 朱玲, 丁建美, 王吉, 王振兴, 徐晓玉, 付志锋*. 桂枝的引药作用机制及其对环丙沙星在小鼠体内分布的影响. 中国科学 2011, 41, 856-862.
15. Liu, J.; Li, R. S.; He, M.; Xu, Z.; Xu, L. Q.; Kang, Y.*; Xue, P.*, Multifunctional SGQDs-CORM@HA nanosheets for bacterial eradication through cascade-activated “nanoknife” effect and photodynamic/CO gas therapy. Biomaterials 2021, 277, 121084.
16. Tao, G.; Xu, X.; Li, R. S.; Liu, F.; Li, N., Nonamplification Multiplexed Assay of Endonucleases and DNA Methyltransferases by Colocalized Particle Counting. ACS Sensors 2021, 6 (3), 1321-1329.
17. He, X.; Zhao, Z.; Xiong, L.-H.; Gao, P. F.; Peng, C.; Li, R. S.; Xiong, Y.; Li, Z.; Sung, H. H. Y.; Williams, I. D.; Kwok, R. T. K.; Lam, J. W. Y.; Huang, C. Z.; Ma, N.; Tang, B. Z.*, Redox-Active AIEgen-Derived Plasmonic and Fluorescent Core@Shell Nanoparticles for Multimodality Bioimaging. Journal of the American Chemical Society 2018, 140 (22), 6904-6911.
18. Wang, J.*; Li, R. S.; Zhang, H. Z.; Wang, N.; Zhang, Z.; Huang, C. Z.*, Highly fluorescent carbon dots as selective and visual probes for sensing copper ions in living cells via an electron transfer process. Biosensors & Bioelectronics 2017, 97, 157-163.
19. Ma, J.; Zhan, L.; Li, R. S.; Gao, P. F.; Huang, C. Z.*, Color Encoded Assays for the Simultaneous Quantification of Dual Cancer Biomarkers. Analytical Chemistry 2017, 89 (16), 8484-8489.
20. Liu, M. L.; Chen, B. B.; Li, R. S.; Li, C. M.; Zou, H. Y.; Huang, C. Z.*, Dendritic CuSe with Hierarchical Side-Branches: Synthesis, Efficient Adsorption, and Enhanced Photocatalytic Activities under Daylight. ACS Sustainable Chemistry & Engineering 2017, 5 (5), 4154-4160.
21. Chen, B. B.; Li, R. S.; Liu, M. L.; Zhang, H. Z.; Huang, C. Z.*, Self-exothermic reaction prompted synthesis of single-layered graphene quantum dots at room temperature. Chemical Communications 2017, 53 (36), 4958-4961.
22. Gao, P. F.; Gao, M. X.; Zou, H. Y.; Li, R. S.; Zhou, J.; Ma, J.; Wang, Q.; Liu, F.; Li, N.; Li, Y. F.; Huang, C. Z.*, Plasmon-induced light concentration enhanced imaging visibility as observed by a composite-field microscopy imaging system. Chemical Science 2016, 7 (8), 5477-5483.
科研项目、成果和专利：
1. 国家自然科学基金(青年项目)，2024.1-2026.12，主持；
2. 国家自然科学基金(地区基金)，2025.1-2029.12，主持；
3. 云南省兴滇英才青年项目，2025-2030，主持；
4. 云南省基础研究计划面上项目，2025.6-2029.5，主持；
5. 云南省基础研究计划青年项目，2024.6-2027.5，主持；
6. 云南大学东陆青年学者人才启动项目2022.7-2028.7，主持；
7. 国家自然科学基金重点项目(22134005)，2022.1-2026.12，参与；
奖励、荣誉和学术兼职：
1. Journal of Pharmaceutical Analysis青年编委
2. 中国分析测试协会分析药学分会委员
3. 北京分析测试科技成果及青年人才成长评价奖；
北京分子科学国家研究中心BMS Junior Fellow 。
