李荣生（博士，副教授）

专业：分析化学

主讲课程：分析化学、仪器分析实验。

团队：生物分析

电子信箱： lirong.sheng@ynu.edu.cn
受教育经历及工作经历：
2011和 2019 年先后获西南大学工学学士和理学博士学位；

2019-2022 年，北京大学 化学与分子工程学院 博士后；

2022-至今，云南大学 副教授。

研究领域和兴趣：
生物传感与治疗。

主要兴趣为：分子（多肽）组装驱动的生物传感和细胞（细菌）功能调控。

论文、专著：

学术论文

1. Zhang, X.; Deng, G.; Chen, H. L.; Wang, Z. S.; Liu, J. Z.; Deng, B. X.; Chen, B. B.; Ye, M. J.; Ma, Y. X.; Zhou, C. H.; Qian, Y.; Chen, L. Q.; Zhen, S. J.; Wen, C.; Huang, C. Z.; Li, N.*; Xiao, W.*; Cao, Q.-e.; Ling, J.*; Li, R. S.*, Intelligent flexible nanospikes of covalent organic frameworks for eliminating biological and chemical threats in water. Matter 2026, 102755.

2. Chen, H.; Liu J.; Liu S.; Yang F.; Yin Q.; Bao, Z.; He, W.; Zhang, X.; Liu, J.-Z.; Wang, Z.; Zhou, T.-C.; Cao, Q.-E; Ling, J.; Li, R. S.*; Intra-Bacterial Supramolecular Assembly of Peptide With RNA Activates MRI/Fluorescence Imaging and Avoids Drug Resistance. Advanced Functional Materials 2026, DOI: 10.1002/adfm.77070.

3. Zhang, R.; Yin, Q.; Li, D.; Yang, F.; Wang, X.; Chen, Y.; Yin, Q.; Wang, Z.; Wu, H.; Wang, L.; Chai, X.; Dong, Y.; Zhou, X.; Ling, J.; Li, R. S.*, Cao, Q., Aggregation-enhanced energy transfer: perovskite dye dual-emission ratiometric fluorescent sensing for antibiotic detection. Sensors and Actuators B: Chemical 2026, 461, 139950.

4. Deng, G.; Wang, Z.; Liu, J.; Chai, X.; Yu, T.; Zhang, X.; Liu, J.-Z.; Liu, Y.; Jiang, X.; Yang, S.; Zhuang, Z.; Ling, J.; Li, R. S.*; A reductive nanospiked covalent organic framework for tri-modal detection and extraction of gold. Chemical Communications 2026, DOI: 10.1039/d6cc03332f.

5. Chai, X.; Lei, C.; Liu, H.; Yang, F.; Yin, D.; Bao, Z.; Liu, J.; Zhang, Q.; Shao, J.*; Li, R. S.*; Ling, J.*; Q.-E. Cao, Colorimetric/fluorescent/SERS/gas pressure four-modal sensing and killing of bacteria via enzyme-responsive aggregation of nanoparticles. Analytical Chemistry 2025, 97, 23108-23119.

6. Huang, Y.; Li, C.; Zhang, X.; Yu, T.; Liu, J.; Li, R. S.*; Ling, J.*; Q. Cao, Transformation of a covalent organic framework from dual pores to single pores and their different properties. Chemical Communications 2025, 61, 15250-15253.

7. Li, R. S.; Liu, J.; Wen, C.; Shi, Y.; Ling, J.; Cao, Q.; Wang, L.; Shi, H.*; Huang, C. Z. *; Li, N.*, Transformable nano-antibiotics for mechanotherapy and immune activation against drug-resistant Gram-negative bacteria. Science Advances 2023, 9 (34), eadg9601.

8. Li, R. S.; Wen, C.; Huang, C. Z.*; Li, N.*, Functional molecules and nano-materials for the Golgi apparatus-targeted imaging and therapy. TrAC Trends in Analytical Chemistry 2022, 156, 116714.

9. Li, R. S.; Liu, J.; Shi, H.*; Hu, P. P.; Wang, Y.; Gao, P. F.; Wang, J.; Jia, M.; Li, H.; Li, Y. F.; Mao, C.*; Li, N.*; Huang, C. Z.*, Transformable helical self-assembly for cancerous Golgi Apparatus disruption. Nano Letters 2021, 21 (19), 8455–8465.

10. Li, R. S.; Liu, J.; Yan, Y.; Su, C.; Lai, T.; Liao, Y.; Li, Y. F.; Li, N.*; Huang, C. Z.*, Aggregation-Enhanced Energy Transfer for Mitochondria-Targeted ATP Ratiometric Imaging in Living Cells. Analytical Chemistry 2021, 93 (34), 11878-11886.

11. Li, R. S.; Liu, J. H.; Yang, T.; Gao, P. F.; Wang, J.; Liu, H.; Zhen, S. J.; Li, Y. F.; Huang, C. Z.*, Carbon Quantum Dots–Europium(III) Energy Transfer Architecture Embedded in Electrospun Nanofibrous Membranes for Fingerprint Security and Document Counterspy. Analytical Chemistry 2019, 91 (17), 11185-11191.

12. Li, R. S.; Gao, P. F.; Zhang, H. Z.; Zheng, L. L.; Li, C. M.; Wang, J.*; Li, Y. F.; Liu, F.; Li, N.*; Huang, C. Z.*, Chiral nanoprobes for targeting and long-term imaging of the Golgi apparatus. Chemical Science 2017, 8 (10), 6829–6835.

13. Li, R. S.; Yuan, B.; Liu, J. H.; Liu, M. L.; Gao, P. F.; Li, Y. F.; Li, M.; Huang, C. Z.*, Boron and nitrogen co-doped single-layered graphene quantum dots: a high-affinity platform for visualizing the dynamic invasion of HIV DNA into living cells through fluorescence resonance energy transfer. Journal of Materials Chemistry B 2017, 5 (44), 8719-8724.

14. Li, R. S.; Zhang, H. Z.; Ling, J.; Huang, C. Z.; Wang, J.*, Plasmonic platforms for colorimetric sensing of cysteine. Applied Spectroscopy Reviews 2016, 51 (2), 129-147.

15. Li, R. S.; Liu, H.; Chen, B. B.; Zhang, H. Z.; Huang, C. Z.; Wang, J.*, Stable gold nanoparticles as a novel peroxidase mimic for colorimetric detection of cysteine. Analytical Methods 2016, 8 (11), 2494-2501.

16. He, X.; Zhao, Z.; Xiong, L.-H.; Gao, P. F.; Peng, C.; Li, R. S.; Xiong, Y.; Li, Z.; Sung, H. H. Y.; Williams, I. D.; Kwok, R. T. K.; Lam, J. W. Y.; Huang, C. Z.; Ma, N.; Tang, B. Z.*, Redox-Active AIEgen-Derived Plasmonic and Fluorescent Core@Shell Nanoparticles for Multimodality Bioimaging. Journal of the American Chemical Society 2018, 140 (22), 6904-6911.

科研项目、成果和专利：

1. 国家自然科学基金(青年项目)，2024.1-2026.12，主持；

2. 国家自然科学基金(地区基金)，2025.1-2029.12，主持；

3. 云南省兴滇英才青年项目，2025-2030，主持；

4. 云南省基础研究计划面上项目，2025.6-2029.5，主持；

5. 云南省基础研究计划青年项目，2024.6-2027.5，主持；

6. 云南大学东陆青年学者人才启动项目2022.7-2028.7，主持；

7. 国家自然科学基金重点项目(22134005)，2022.1-2026.12，参与；

奖励、荣誉和学术兼职：

1. Journal of Pharmaceutical Analysis青年编委

2. 中国分析测试协会分析药学分会委员

3. 北京分析测试科技成果及青年人才成长评价奖；

4. 北京分子科学国家研究中心BMS Junior Fellow 。