Xiao-Dong YANG

Xiao-Dong YANG

Ph.D.

Professor

Doctor Advisor

Office: Chemistry Building 601

Tel.: 86-(0)871-65033644-8899

Email: xdyang@ynu.edu.cn

Address: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan University, No. 2 Cuihu North Road, 650091 Kunming, P.R.China

Brief Introduction

Professor, Yunnan University (2010 - )

Associate Professor, Yunnan University (2005 - 2010)

Visiting Scholar, University of Pennsylvania (2015 - 2016)

Ph.D., Yunnan University (2005 - 2009)

M.S., Yunnan University (2000 - 2003)

Research Interests

Organic synthetic chemistry, total synthesis and medicinal chemistry

Foundation and Projects

1. National Natural Science Foundation of China, Studies on the synthesis, biological activity and mechanism of natural-product-like compounds containing the tetracyclic skeleton of Brazilin, No. 21662043 (2017-2020), responsible.

2. National Natural Science Foundation of China, Studies on the design, synthesis and antitumor activity of mTOR signaling pathway inhibitors based on natural product pharmacophores, No. 21462049 (2015-2016), responsible.

3. National Natural Science Foundation of China, Studies on the synthetic methods of aryl quaternary carbon-type Amaryllidaceae alkaloids, No.21062026 (2011-2013), responsible.

4. National Natural Science Foundation of China, Studies on the design, synthesis and antitumor activity of natural product-like hybrid compounds between dihydrobenzofuran and imidazole, No. 30960460 (2010-2012), responsible.

5. Natural Science Foundation of Yunnan Province, Studies on the design, synthesis and antitumor activity of molecular targeted drugs: Novel protein kinases inhibitors, No. 2013FA028 (2013-2016), responsible.

6. Natural Science Foundation of Yunnan Province, Studies on the synthesis and structure-activity relationships of compound libraries of imidazolium salts with antitumor activity, No. 2012FB113 (2012-2015), responsible.

Representative Publications

1. Xiaodong Yang*, Byeong-Seon Kim, Minyan Li, Patrick J. Walsh*, Palladium-catalyzed selective α-alkenylation of pyridylmethyl ethers with vinyl bromides, Org. Lett., 2016, 18(10), 2371-2374.

2. Xuequan Wang, Hongbin Zhang*, Xiaodong Yang*, Jingfeng Zhao, Chengxue Pan, Enantio-selective total synthesis of (+)-brazilin, (–)-brazilein and (+)-brazilide A, Chem. Commum., 2013, 49(47), 5405-5407.

3. Wen Chen, Jian Ren, Minshou Wang, Lingjing Dang, Xianfu Shen, Xiaodong Yang*, Hongbin Zhang*, Iodine mediated deprotection of N-tert-butanesulfinyl amines: a functional group compatible method, Chem. Commum., 2014, 50(47), 6259-6262.

4. Lan-Xiang Liu, Xue-Quan Wang, Bei Zhou, Li-Juan Yang, Yan Li*, Hong-Bin Zhang*, Xiao-Dong Yang*, Synthesis and antitumor activity of novel N-substituted carbazole imidazolium salt derivatives, Sci. Rep., 2015, 5, 13101.

5. Xue-Quan Wang, Lan-Xiang Liu, Yan Li, Cheng-Jun Sun, Wen Chen, Liang Li, Hong-Bin Zhang, Xiao-Dong Yang*, Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents, Eur. J. Med. Chem., 2013, 62, 111-121.

6. Lan-Xiang Liu, Xue-Quan Wang, Ju-Ming Yan, Yan Li, Cheng-Jun Sun, Wen Chen, Bei Zhou, Hong-Bin Zhang, Xiao-Dong Yang*, Synthesis and antitumor activities of novel dibenzo[b,d]furane imidazole hybrid compounds, Eur. J. Med. Chem., 2013, 66, 423-437.

7. Xiao-Liang Xu, Chun-Lei Yu, Wen Chen, Ying-Chao Li, Li-Juan Yang, Yan Li*, Hong-Bin Zhang*, Xiao-Dong Yang*, Synthesis and antitumor activity of novel 2-substituted indoline imidazolium salt derivatives, Org. Biomol. Chem., 2015, 13(5), 1550-1557.

8. Jin-Mei Liu, Min Wang, Yun-Jing Zhou, Ju-Ming Yan, Li-Juan Yang*, Yan Li*, Hong-Bin Zhang, Xiao-Dong Yang*, Novel 3-substituted fluorine imidazolium/triazolium salt derivatives: synthesis and antitumor activity, RSC Adv., 2015, 5(78), 63936-63944.

9. Cheng-Jun Sun, Wen Chen, Yan Li, Lan-Xiang Liu, Xue-Quan Wang, Li-Juan Li, Hong-Bin Zhang*, Xiao-Dong Yang*, Design, synthesis and antitumor activity of novel 8-substituted 2,3,5,6-tetrahydrobenzo[1,2-b:4,5-b']difuran imidazolium salt derivatives, RSC Adv., 2014, 4(31), 16312-16319.

10. Wen-Jian Song, Xiao-Dong Yang*, Xiang-Hui Zeng, Xiao-Liang Xu, Gao-Lan Zhang, Hong-Bin Zhang*, Synthesis and cytotoxic activities of novel hybrid compounds of imidazole scaffold-based 2-substituted benzofurans, RSC Adv., 2012, 2(11), 4612-4615.

Patents

1. Xiao-Dong Yang, Hong-Bin Zhang, Xue-Quan Wang, Wen Chen, Liang Li, Jian-Ping Liu, 2-Benzyl substituted benzofuran-imidazolium salt compounds and their preparation method, ZL 201210237371.2, 2014.10.15.