School of Chemical Science and Technology
Add:No.2 North Cuihu Road, Kunming, P. R. China
Sichuan XU
Ph.D.
Professor
Specialty: Biological Physical Chemistry
Tel.: 0086-871-65039937
Email: sichuan@ynu.edu.cn
Address: Yunnan University’s Old Campus, Chemistry Building 223#, School of Chemical Science and Technology, Yunnan University, Cuihu North Road 2#, Kunming City, Post Code 650091, P. R. China
Education backgrounds:
(1) 9/1979 to 7/1983; BS in Physical Chemistry
Department of Chemistry, Zhejiang University, Hangzhou, China
(2) 9/1986 to 7/1989, MS in Physical Chemistry
(3) 9/1996 to 7/1999, PhD in Physical Chemistry including Chemical Physics
College of Chemistry & Molecular Engineering, Peking University, Beijing, China
Research experiences
1. Professor, Yunnan University, (9/2005 - present)
2. Visiting Professor, Institute of Chemistry, Chinese Academy of Sciences (5/2008
- 7/2011)
3. Associate Researcher, Concordia University, Canada (11/2003 - 8/2005)
4. K.C. Wong Fellow, Département de Chimie, Ecole Normale Supérieure,
Paris, France (11/2002 - 10/2003)
5. Postdoctoral Researcher, Institute of inorganic chemistry, Zürich University, Switzerland (11/2001 - 10/2002)
6. Associate Professor, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China (2/2001 - 11/2001)
7. Postdoctoral researcher, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China (7/1999 - 6/2001)
Teaching:
Courses: "General Chemistry", "Physical Chemistry"
Research fields and interests:
1. Protein science and engineering;
2. Neural drug discovery and application;
3. Anticancer drug discovery and development;
Research interests: studying physical and chemical issues in biological systems by means including: organic synthesis, separation and extraction, determination and analysis using spectra, molecular modeling, theoretical basis and calculation, animal experiments and volunteer researches.
Foundation and Projects
1．NSFC 21163024 (2012/01-2015/12), responsible
2、NSFC 21563032 (2016/01-2019/12), responsible
Representative Publications
(1) Ming WANG, Wei XIE, Aijing LI and Sichuan XU*. The Structural Basis and Mechanism of Chiral Benzedrine Molecules Interacting with Third Dopamine Receptor. Chirality, accepted.
(2) Wei Xie, Ming Wang, Aijing Li & Si-Chuan Xu*. Molecular Dynamics Simulation of D-Benzedrine Transmitting through Molecular Channels within D3R. Journal of Biomolecular Structure and Dynamics, 2016, DOI: 10.1080/07391102. 2016.1190947.
(3) Xie, W., Xu, Z.R., Wang, M., & Xu, S.C. *. Molecular Dynamics Simulation for Levo-Benzedrine to Transmit through Molecular Channels within D3R. Acta Phys.-Chim. Sin., 2016, 32, 907-920.
(4) Shaoming CHI, Wei XIE, Jiwei ZHANG, Sichuan XU*. Theoretical insight into the structural mechanism for the binding of vinblastine with tubulin. Journal of Biomolecular Structure and Dynamics, 2015, 33, 2234-54.
(5) Xing Chengfen，Yuan Hongbo，Xu Sichuan，An Hailong，Niu Ruimin，Zhan Yong. Nucleobase- Functionalized Conjugated Polymer for Detection of Copper(II). ACS Applied Materials & Interfaces, 2014, 6(12): 9601-9607.
(6) Guojun Shi, Yue Wang, Shaoming Chi, Qiang Shi, Maofa Ge, Shu Wang, Xingkang Zhang and Sichuan Xu*. Structural Insight into the Mechanism of Epothilone A Bound to Beta-Tubulin and its Mutants at Arg282Gln and Thr274Ile. The Journal of Biomolecular Structure and Dynamics, 2012, 30(5), 541-555.
(7) Sichuan Xu*, Shaoming Chi, Yi Jin, Qiang Shi, Maofa Ge, Shu Wang and Xingkang Zhang. Molecular Dynamics Simulation and Density Functional Theory Studies on the Active Pocket for Paclitaxel Binding to Tubulin. J Molecular Modeling, 2012, 18, 377-391.
(8) Yue WANG, Fuyong BIAN, Shengrong DENG, Qiang SHI, Maofa GE, Shu WANG, Xingkang ZHANG, and Sichuan XU*. The Key Residues of Active Sites on the Catalytic Fragment for Paclitaxel Interacting with Poly(ADP-Ribose) Polymerase. The Journal of Biomolecular Structure and Dynamics, 2011, 28(6), 881-895。
(9) XU Sichuan*, DENG Shengrong, MA Liying, SHI Qiang, ZHANG Xingkang, GE Maofa. The Tautomerization of H2NCH2C(OH)NH to H2NCH2CONH2 in the Interstellar Medium. China Science G，2011，54(1), 156-164.
(10) SICHUAN XU*, SHENGRONG DENG, LIYING MA, QIANG SHI, MAOFA GE, XINGKANG ZHANG. The Proton-Coupled Proton Transfer Mechanism, H2O Catalysis, and Hydrogen Tunneling Effects in the Reaction of HNCH2 with HCOOH in the Interstellar Medium. International Journal of Quantum Chemistry, 2010, 110, 2671-2682.
(11) XU SiChuan*, WANG Ning. Theoretical Studies of Aminoacetonitrile Production in the Interstellar Medium. Acta Phys.-Chim. Sin., 2007, 23(2): 212-216.
(12) Denise M. Koch, Céline Toubin, Sichuan Xu, Gilles H. Peslherbe, and James T. Hynes. Concerted Proton-Transfer Mechanism and Solvation Effects in the HNC/HCN Isomerization on the Surface of Icy Grain Mantles in the Interstellar Medium. J. Phys. Chem. C, 2007, 111 (41), 15026 –15033.
(13) Xu Si-Chuan*, Ai Xicheng, Sun Zhaoyong, Zhang Qiyuan, Zhang Xingkang. Spectroscopy Studies on the Telomeric DNA Base Sequence Repeats. Chinese Science Bulletin, 2002, 47, 108-111.
(14) ZHANG Huijuan, WANG Peng, WANG Xuefei, FENG Juan, XU Sichuan, AI Xicheng, ZHANG Xingkang, ZHANG Jianping. Mechanism of intramolecular charge transfer in DNA helix as probed by the use of the fluorescent 2-aminopurine. China Science B, 2004, 47(5), 367-372.
(15) XU Si Chuan*, SUN Zhao-Yong, AI Xi-Cheng, FENG Juan, ZHANG Qi-Yuan, ZHANG Xing-Kang, YU Fei, TANG Chong-Qin, KUANG Ting-Yun. Ultrafast Spectral Studies of the primary Processes of Photosynthesis in Spinach and Water Hyacinth Leaves. Acta Botanica Sinica, 2000, 42, 1235-1242.
(16) Xu Si-Chuan*, Sun Zhaoyong, Ai Xicheng, Feng Juan, Zhang Qiyuan, Zhang Xingkang, Yu Fei, Tang Chongqin, Li Liangbi, Kuang Tingyun. Ultrafast electron transfer and energy conversion in the Isolated Chloroplasts. China Science B, 2001, 31(4), 366-380.
(17) Sichuan Xu, Xinsheng Zhao*. Theoretical investigation of reaction of ClONO2with H2O on Water Clusters. J. Phys. Chem. A, 1999, 103, 2100-2106.
(18) Si Chuan Xu*, Rui Guo, Sheng Long Wang. Research of the Model Reactions of HOCl with HCl on Water Clusters. Chem. Phys. Lett. 1999, 313, 617-625.
(19) Si Chuan Xu*. Hydrogen Bond and Cooperative Effect in the Reaction of HOCl with HCl on Water Clusters. J. Chem. Phys. 1999, 111, 2242-2254.
