School of Chemical Science and Technology
Add:No.2 North Cuihu Road, Kunming, P. R. China
Yun-Song WANG
Ph.D.
Professor
Master Advisor
Office: Chemistry Building 517
Tel.: 86-(0)871-65033715
Email: wangys@ynu.edu.cn
Address: School of Chemical Science and Technology, Yunnan University, 2 North Cuihu Road, Kunming 650091, P.R.China
Brief Introduction
Visiting Scholar, University of North Carolina at Chapel Hill, USA (2016-2017)
Professor, Yunnan University (2015- present)
Associate Professor, Yunnan University, China, (2005-2015)
Assistant Researcher, the State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, China (2004-2005)
Engineer,Yunnan Institute of Tobacco Science, China (1996-2001)
Assistant Engineer,Yunnan Chemical Research Institute, China (1991-1993)
Ph.D., Kunming Institute of Botany, Chinese Academy of Sciences, China (2001-2004)
M.S., Organic Chemistry, Yunnan University, China (1993-1996)
B.S., Analytic Chemistry, Lanzhou University, China (1987-1991)
Research Interests
Organic Chemistry, Medicinal Chemistry, Applied Chemistry
Research interest: Nature has proven to be an excellent, continuing source of medicines for the treatment of a wide spectrum of diseases. Natural products have played a key role in drug discovery and are still a prolific source of novel lead compounds or pharmacophores for medicinal chemistry. Unprecedented chemical structures, novel chemotypes, often pave the way to investigate new biology and to explore new pathways and targets. Most natural products leads are frequently optimized through structural modification to achieve the final candidate. My recent research interest is to combine the fields of the most advanced natural products chemistry and synthetic medicinal chemistry as well as cutting-edge life science technologies to design and discover herbal medicine-based bioactive natural products and their analogs as drug candidates, with emphasis on carbazole alkaloids, coumarins and cyclic peptides.
Foundation and Projects
National Nature Science Foundation of China (No. 21462048) (2015-2018), responsible
National Nature Science Foundation of China (No. 21162038) (2012-2015), responsible
Science Foundation of Guizhou Institute of Tabacco Science (2013-2016), responsible
Science Foundation of Guizhou Institute of Tabacco Science (2012-2015), responsible
Joint key project of Yunnan Provincial Science and Technology Department and Yunnan Provincial Public Security Department (No. 2008CA012-9) (2009-2011), responsible
Science Foundation of Yunnan Province (No. 2006B0003Q) (2006-2009), responsible
Science Foundation of Yunnan University (No. 2005Z001A) (2005-2008), responsible
Foundation of the Young-Middle-Aged Backbone Teachers of Yunnan University (2006-2009), responsible
National Nature Science Foundation of China (No. 21262040) (2013-2016), participant
National Nature Science Foundation of China (No. 20862018) (2009- 2011), participant
Representative Publications
[1] Yun-Song Wang, Hong-Pin He, Yue-Mao Shen, Xin Hong, Xiao-Jiang Hao. Two New Carbazole Alkaloids from murraya koenigii. J. Nat. Prod. 2003, 66, 416-418.
[2] Yun-Song Wang, Zheng-Qi Wen, Bi-Tao Li, Hong-Bin Zhang, Jing-Hua Yang. Ethnobotany, phytochemistry, and pharmacology of the genusLitsea: An update. Journal of Ethnopharmacology, 2016, 181：66-107.
[3] Yun-Song Wang, Hong-Ping He, Jing-Hua Yang, Yue-Mao Shen, Jun Zhou, Xiao-Jiang Hao. A New Cyclopeptide from Clausena anisum-olens. Helv. Chim. Acta. 2005, 88,2345-2348.
[4] Yun-Song Wang, Rong Huang, Yan Li, Wen-Bin Shang, Fei Chen, Hong-Bin Zhang, Jing-Hua Yang. Panamonon A and B, a pair of novel tetrahydrobenzofuran derivatives from Litsea panamonja (Nees) Hook. f. Phytochemistry Letters, 2013, 6, 26-30.
[5] Yuan-Hong Zhao, Yun-Song Wang, Hong-Wei Sun, Liang Li, Hong-Bin Zhang. Ullmann reaction in tetraethyl orthosillicate: a novel synthesis of triarylamines and diaryl ethers. Chem. Commun.2007, (30), 3186-3188.
[6] Yun-Song Wang, Hong-Pin He, Jing-Hua Yang, Ying-Tong Di, Ning-Hua Tan, Xiao-Jiang Hao. Clausenain B, a phenylalanine-rich cyclic octapeptide from Clausena anisum-olens. J Brail Chem Soc. 2009, 20(3), 478-481.
[7] Yun-Song Wang, Rong Huang, Ning-Zhong Li, Jing-Hua Yang. Coumarins from Clausena anisum-olens Merr. Biosci. Biotech. Biochem.2010,74 (7), 1483-1484.
[8] Yun-Song Wang, Zhen Liao, Yan Li, Rong Huang, Hong-Bing Zhang, Jing-Hua Yang. A new megastigmane diglycoside from Litsea glutinosa(Lour.) C. B. Rob. J Brail Chem Soc. 2011, 22(11), 2234-2238.
[9] Yun-Song Wang, Rong Huang, Hao Lu, Feng-Ya Li, Jing-Hua Yang. A New 2′-Oxygenated Flavone Glycoside from Litsea glutinosa (Lour.) C. B. Rob. Biosci. Biotech. Biochem, 2010, 74(3), 652-654.
[10] Yun-Song Wang, Zhen Liao, Hong-Kun Zhu, Xiao-Fei Feng, Kun-Ming-Jiang, Rong Huang, Na Zhu, Jing-Hua Yang. Megastigane O–glucopynanosides from Litsea glutinosa. Chem. Nat. Comp. 2012,48(2), 346-3492.
[11] Yun-Song Wang, Rong Huang, Ning-Zhong Li, Hong-Yi Xu, Jing-Hua Yang. Triterpenes from Stachyurus himalaicus var. himalaicus Hook. f. et Thoms. ex Benth. Molecules 2010, 15, 2096-2102.
[12] Yun-Song Wang, Hong-Yi Xu, Da-Xiang Wang, Jing-Hua Yang. A New O-terpenoidal coumarin from Clausena anisum-olens Merr.Molecules, 2009,14 (2):771-776 .
[13] Yun-Song Wang, Rong Huang, Liang Li, Hong-Bin Zhang, Jing-Hua Yang. O-terpenoidal coumarins from Clausena anisum-olens. Biochem.Sys. Ecol. 2008, 36(10), 801-803.
[14] Yun-Song Wang, Hong-Pin He, Jing-Hua Yang, Ying-Tong Di, Xiao-Jiang Hao. New Monoterpenoid Coumarins from Clausena anisum-olens. Molecules 2008, 13, 931-937.
[15] Yun-Song Wang, Jing-Hua Yang, Shi-De Luo, Hong-Bin Zhang, Liang Li. New Cytotoxic Steroid from Stachyurus himalaicus var.himalaicus. Molecules, 2007, 12, 536-542.
[16] Yun-Song Wang, Feng-Ya Li, Rong Huang, Yan Li, Xiao-Fei Feng, Jing-Hua Yang. Chemical Constituents from Pteris multifida Poir.Chem. Nat. Comp. 2013, 49 (3), 539-541.
[17] Yun-Song Wang, Hong-Pin He, Xin Hong, Qing Zhao, Xiao-Jiang Hao. A New Binary Carbazole Alkaloid from Murraya koenigii. Chinese Chemical Letters, 2002,13, 849-850.
[18] Jing-Hua Yang, Hao Lu, Rong Huang, Yun-Song Wang. Flavonoids from leaves and twigs of Stachyurus himalaicus var. himalaicus.Chem. Nat. Comp. 2011, 47 (1), 112-113.
[19] Yun-Song Wang, Rong Huang, Jing-Hua Yang. Chemical constituents of Litsea szemaois. Chem. Nat. Comp. 2011, 47 (1), 122-123.
[20] Ying-Tong Di, Hong-Ping He, Yun-Song Wang, Liang-Bo Li, Yang Lu, Jian-Bo Gong, Xin Fang, Ning-Chuan Kong, Shun-Lin Li, Hua-Jie Zhu, Xiao-Jiang Hao. Isolation, X-ray crystallography, and computational studies of calydaphninone, a new alkaloid from Daphniphyllum calycillum.Org. Lett, 2007,9(7), 1355-1358.
[21] Yun-Song Wang, Hao Lu, Rong Huang, Jing-Hua Yang, Hong-Bin Zhang. Total Synthesis of Clausenain B. 14th Tetrahedron Symposium,Vienna, 2013, 06.25-28.
[22] Wen-Bin Shang, Jing-Hua Yang, Rong Huang, Hong-Bin Zhang, Yun-Song Wang*. Synthesis of Pyrano[3,2-a]carbazole Alkaloids. 14th Tetrahedron Symposium,Vienna, 2013,06.25-28.
[23] Yang Jing-Hua, Li Liang, Li Zi-Yan, Wang Yun-Song. Diterpenoid alkaloids from Aconitum episcopale, Phytochemistry, 1999, 50(2), 345-348.
[24] Wu YQ, Kitajima M, Kogure N, Wang YS, Zhang RP, Takayama H. Kopsiyunnanines F and isocondylocarpines: new tubotaiwine-type alkaloids from Yunnan Kopsia arborea. J Nat Med 2009,63, 283-289.
[25] Yuqiu Wu, Mariko Kitajima, Noriyuki Kogure, Yunsong Wang, Rongping Zhang, Hiromitsu Takayama. Two New Aspidosperma Indole Alkaloids from Yunnan Kopsia arborea. Chem Pharm Bul 2010 58, 961-963.
Awards & Honors
"Hongyun gardener Award" Excellent Teacher Award (2015)
Prize for Progress in Science and Technology of Yunnan Province (2014 and 2007)
Natural Science Award of Yunnan Province 2011
Yunnan University Teaching Achievement Award for 1st prize (2011 and 2008)
the 11th "Challenge Cup" national university student extracurricular academic science and technology competition for 3rd prize (2010)
the 5th Youth Academic Science and technology competition in Yunnan Universities for 2nd prize (2010)
Students' extracurricular academic science and technology competition of Yunnan University for Outstanding Winner of undergraduate students (2009)
Excellent Academic Advisor of Yunnan University (2010)
National Great Course (2007)
The Young-Middle-Aged Backbone Teachers of Yunnan University (2006)
Appointments & Positions
Review expert of China Food and Drug Administration (CFDA)
Guest Professor of Guizhou Institute of Tabacco Science
Review expert of Yunnan Provincial Food and Drug Administration
Member of Yunnan Provincial Food Quality and Safety Association
