Jun Lin

Jun Lin

Ph.D.

Professor

Doctor Advisor    

Office: Chemistry Building   

Tel.: 86-(0)871-65031633      

Email: linjun@ynu.edu.cn     

Address: School of Chemical Science and Technology, Yunnan University 2 North Cuihu Road, 650091 Kunming, P. R. China   

Brief Introduction

(Associate/Assistant) Professor, Yunnan University (1993 - present)

Visiting Scholar, University of Arizona (1996.8 – 1998.1)

Senior Visiting Scholar, University of Oxford (2002.8 – 2003.8)

Senior Research Scientist, MIT (2016.1 – 2016.4)

Ph.D., Kunming Institute of Botany, Chinese Academy of Sciences (1995 - 1998)

M.S., Yunnan University (1990 - 1993)

Research Interests

Organic synthesis, Drug synthesis and Organic synthesis methodology

Main interests: (1) Study on the design and synthesis of active pharmaceutical natural product-like heterocyclic compounds; (2) Small molecule chiral catalytic reaction and asymmetric synthesis; (3) Supramolecular chemistry of complex natural products; (4) Extraction, synthesis and activity of pesticide active compounds with high efficiency and low toxicity.

Foundation and Projects

1.     Design, Synthesis and Antitumor Activity Study of Novel Anti-angiogenic Tyrosine Kinase Inhibitors, NSFC U1202221, (2013.1-2016.12), responsible

2.       Diversity oriented synthesis of   polycyclic indole heterocyclic compounds and their antitumor activities, NSFC   21262042, (2013.1-2016.12), responsible 3.       Study on the synthesis and antitumor   activity of a variety of natural product-like heterocyclic compounds, project   of “Yunling Scholar”, (2015.1-2019.12), responsible

Representative Publications

1.     Shengjiao Yan, Yulan Chen, Lin Liu, Nengqin He and Jun Lin*, Three-component solvent-free synthesis of highly substituted bicyclic pyridines containing a ring-junction nitrogen, Green Chemistry, 2010, 12 (11), 2043 - 2052.

2.     Fuchao Yu, Shengjiao Yan,* Ling Hu, Yongchao Wang, and Jun Lin*, Cascade Reaction of Isatins with Heterocyclic Ketene Aminals: Synthesis of Imidazopyrrolo-quinoline Derivatives, Organic Letters, 2011, 18, 4782-4785.

3.     Fuchao Yu, Rong Huang, Hangchen Ni, Juan Fan, Shengjiao Yan* and Jun Lin*, Three-Component Stereoselective Synthesis of Spirooxindole Derivatives, Green Chemistry, 2013, 15, 453-462.

4.     Liang Xi, Jian-Qiang Zhang, Zhi-Cheng Liu, Ji-Hong Zhang, Ju-Fang Yan, Yi Jin* and Jun Lin*, Novel 5-anilinoquinazoline-8-nitro derivatives as inhibitors of VEGFR-2 tyrosine kinase: synthesis, biological evaluation and molecular docking', Organic & Biomolecular Chemistry, 2013, 11, 4367–4378.

5.     Yi-Chuan Zhang, Zhi-Cheng Liu, Rui Yang, Ji-Hong Zhang, Sheng-Jiao Yan^* and Jun Lin^*, Regioselective construction of 1,3-diazaheterocyclefused[1,2-a][1,8]naphthyridine derivatives via cascade reaction of quinolines with heterocyclic keteneaminals: a joint experimental-computational approach, Organic & Biomolecular Chemistry, 2013, 11, 7276–7288.

6.     Bei Zhou, Zhi-Cheng Liu, Wen-Wen Qu, Rui Yang, Xin-Rong Lin, Sheng-Jiao Yan,^* and Jun Lin^*, An environmentally benign, mild, and catalyst-free reaction of quinones with heterocyclic ketene aminals in ethanol: site-selective synthesis of rarely fused [1,2-a]indolone derivatives via an unexpected anti-Nenitzescu strategy, Green Chemistry, 2014, 16 (9), 4359-4370.

7.     Xue-Bing Chen, Zhi-Cheng Liu, Xin-Rong Lin, Rong Huang, Sheng-Jiao Yan,^* and Jun Lin^*, Highly Diastereoselective Convergent Synthesis of Polycyclic Pyrroles with Consecutive Quaternary Stereocenters: Cascade Construction of Multiple C−C and C−Hetero Bonds, ACS Sustainable Chemistry & Engineering, 2014, 2, 2391-2398.

8.     Xue-Bing Chen, Zhi-Cheng Liu, Li-Fen Yang, Sheng-Jiao Yan,^* and Jun Lin^*, A Three-Component Catalyst-Free Approach to Regioselective Synthesis of Dual Highly Functionalized Fused Pyrrole Derivatives in Water–Ethanol Media: Thermodynamics versus Kinetics, ACS Sustainable Chemistry & Engineering, 2014, 2, 1155−1163.

9.     Yongchao Wang, Dong Li, Jun Lin^* and Kun Wei^*, Organocatalytic Asymmetric Michael Addition of Aldehydes and Ketones to Nitroalkenes Catalyzed by Adamantoyl L-Prolinamide, RSC Advances, 2015, 5, 5863–5874.

10.  Jian-Qiang Zhang, Ke Li, Kun-Ming Jiang, Yan-Wei Cong, Shao-Ping Pu, Xiao-Guang Xie, Yi Jin^* and Jun Lin^٭, Development of an oral satraplatin pharmaceutical formulation by encapsulation with cyclodextrin, RSC Advances, 2016, 6, 17074-17082

 

Patents

[1]   Yi Jin, Jun Lin, Li-Ping-Shi, Preparation and application of Multi halogen substituted phenyl cyanide-quinazolone compounds, CN ZL201310242148.1, 2015-10-14.

[2]  Yi Jin, Jun Lin, Liang Xi, Sheng-Jiao Yan, Ling Hu, Juan Fan, Preparation and application of a class of Quinazoline aryl ureas, CN ZL201210430235.5, 2015-11-20.

APPOINTMENTS & POSITIONS

Member of Chinese Chemical Society, China, 1993-present

Director of the Yunnan Chemical and Chemical Engineering Society, China, 2006-present