Jin Yi

Jin Yi 

Ph.D. 

Associate Professor

Master Advisor

Office: Chemistry Building 504

Tel.: 86-(0)871-15394972667

Email: jinyi@ynu.edu.cn

Address: School of Chemical Science and Technology, Yunnan University, 2 North Cuihu Road, 650091 Kunming, P.R.China

Brief Introduction

(Associate) Professor, Yunnan University (2006 - )

Visiting Scientist, University of Michigan, Ann Arbor Campus (2016 - 2017)

Guest Professor of Chemistry, ChengDu Diao Pharmaceutical Company, (2008.09)

Postdoc Fellow/Research Scientist, KunMing Institute of Botany, CAS (2006 - 2007)

Ph.D., ShangHai Institute of Materia Medica, CAS, (2001 - 2006)

M.S., ShangHai Institute of Materia Medica, CAS, (2001 - 2002)

(Assistant) Professor, KunMing Institute of Precious Metals (1998 - 2001),

B.S., University of LanZhou of China (1994 - 1998)

Research Interests

Medicinal Chemistry and Organic Synthesis Computer Aided Drug Design and Molecular Modeling Biochemistry

Foundation and Projects 

Design, synthesis and biological activity evaluation of tumor inhibitors based on the structure of VEGFR-2 kinase protein  (Nos:20902079)

 

Design, synthesis and antitumor activity of a new type of novel double ring and the tubulin polymerization inhibitor (Nos:21262043)

Representative Publications 

[1]   A. Fujishima, K. Honda, Electrochemical photolysis of water at a semiconductor electrode, Nature 1972, 238, 37-38.

[2]   J. A. Turner, Sustainable Hydrogen Production, Science 2004, 305, 972-974.

Patents 

1.    Xi, L.; Wu, D.; Zhu, H.; Zhang, C.; Jin, Y.*; Lin, J. Improved and Large-Scale Synthesis of N-methyl-D-aspartic Acid. Current Organic Synthesis 2015, 12, 197-201.

2.    Zhang, J.; Wu, D.; Jiang, K.; Zhang, D.; Zheng, X.; Wan, C.; Zhu, H.; Xie, X.; Jin, Y.*; Lin, J. Preparation, spectroscopy and molecular modelling studies of the inclusion complex of cordycepin with cyclodextrins. Carbohydrate Research 2015, 406, 55-64.

3.    Gao, R.; Jin, Y.; Yang, Q.; Sun, B.; Lin, J. Study of stability and drug-excipient compatibility of estradiol and pharmaceutical excipients. Journal Of Thermal Analysis And Calorimetry 2015, 120, 839-845.

4.    Ye, Q.; Li, X.; Jin, Y.*; Yu, J.; Chang, Q.; Jiang, J.; Yan, C.; Li, J.; Liu, W.  1-(2,6-Difluorobenzoyl)-Crystal Structures and Catalytic activity of dirhodium(II) Complexes with Axial Picoline Ligandsenyl)urea. Inorganica Chimica Acta 2015, 4(8), 540-546

5.    An, X.; Liu, H.; Xu, Z.; Jin, Y.; Peng, X.; Yao, Y.; Geng, M.; Long, Y. Discovery of potent 1H-imidazo[4,5-b]pyridine-based c-Met kinase inhibitors via mechanism-directed structural optimization. Bioorganic & Medicinal Chemistry Letters 2015, 25, 708-716.

6.    Jiang, K.; Dai, X.; Li, K.; Wu, D.; Zhang, J.; Jin, Y.*; Lin, J. Synthesis and In-Vitro Cytotoxicity of (E)-N,2,3-Triarylacrylamide Derivatives as Analogs of Combretastatin A-4. Medicinal Chemistry 2015, 11.

7.    Jiang, J.; Wang, X.; Zhang, Y.; Jin, Y.* Lin, J. Advances in the inhibitors of Janus Kinase. Medicinal Chemistry 2014, 4(8), 540-546

8.    Zhang, J.; Li, K.; Cong, Y.; Pu, S.; Zhu, H.; Xie, X.; Jin, Y.* Lin, J. Preparation, characterisation and bioactivity evaluation of the inclusion complex formed between picoplatin and gamma-cyclodextrin. Carbohydrate Research 2014, 396, 54-61.

9.    Zhi, Y.; Gao, L.; Jin, Y.; Tang, C.; Li, J.; Li, J.; Long, Y. 4-Quinolone-3-carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase 1B. Bioorganic & Medicinal Chemistry 2014, 22, 3670-3683.

10.  Xiao, C.; Li, K.; Huang, R.; He, G.; Zhang, J.; Zhu, L.; Yang, Q.; Jiang, K.; Jin, Y.* Lin, J. Investigation of inclusion complex of Epothilone A with cyclodextrins. Carbohydrate Polymers 2014, 102, 297-305.

11.   Fan, J.; Yang, Q.; He, G.; Xie, X.; Zhu, H.; Jin, Y.* Lin, J. Efficient and regioselective synthesis of bicyclic pyrrolidones or bicyclic pyridones by cyclocondensation of heterocyclic ketene aminals with nitro-phenylpropiolate. Rsc Advances 2014, 4, 28852-28855.

APPOINTMENTS & POSITIONS