Yanping He

Yanping He 

Ph.D. 

Full Professor

Master Advisor

Office: Chemistry Building 413

Tel.: 86-(0)871-65031119

Email: yphe@ynu.edu.cn

Address: School of Chemical Science and Technology, Yunnan University, 2 North Cuihu Road, 650091 Kunming, P.R.China

Brief Introduction

Full Professor, Yunnan University (2011 - )

Visiting Scientist, University of Wisconsin-Milwaukee (2013 - 2014)

Associate Professor, Yunnan University  (2005 - 2011)

Lecturer, Yunnan University  (2004 - 2005)

Ph.D., Fudan University (2000 - 2004)

M.S., Yunnan University (1997 - 1999)

B.S., Yunnan University (1990 - 1994)

 

Research Interests

Computer aided drug design, H (e.g. IV-RT inhibitors, HCV NS5B polymerase inhibitors, anti-cancer drugs), organic synthesis, Structure activity relationship (SAR) research,  

Foundation and Projects

NSFC 21262044 (2013 - 2016), responsible

NSFC 30960459 (2010 - 2012), responsible

NSFC 30560179 (2006 - 2008), responsible

National major drug discovery project(2014-2016), responsible

 

Representative Publications

1、X.J. Zhang，L.H. Lu， R.R. Wang， Y.P Wang，H.R Luo，C.C. Lai， L.M. Yang，Y.P. He*，Y.T. Zheng*，DB-02, a C-6-Cyclohexylmethyl Substituted Pyrimidinone HIV-1 Reverse Transcriptase Inhibitor with Nanomolar Activity, Displays an Improved Sensitivity against K103N or Y181C Than S-DABOs，PLos One，2013，8（11）。

2、D.C. Wu， D.M. Zhuang，X.F. Liu，L.H Lu，H. wang，C. Li， C. C. Lai，J.Y. Li *，Y.P

He*，Synthesis and Biological Evaluation of Novel Hydroxyl –phenethyl -S-DACOs as High Active Anti-HIV Agents，Letters in Drug Design and Discovery，2013，10（3）：271-276。

3、Y.P. Wang, W.L.Yan, Guo Q., Y.P. He *. HQSAR Studies on S-DABO Derivatives as HIV-1

Reverse Transcriptase Inhibitors，Chinese Sci. Bull，2013，58：1-6

4、D.C. Wu, Y.P. He *. Research Progress in HCV Non-nucleoside NS5B Polymerase Inhibitors，Progress in Chemistry，2012，24（11）：2255-2267

5、Y.P He *，J. Long， S.S. Zhang，C. Li，C. C. Lai，C.S. Zhang，D.X. Li，D.H. Zhang，H. Wang，Q.Q. Cai， Y.T. Zheng，Synthesis and biological evaluation of novel dihydro-aryl/ alkylsulfanyl-cyclohexylmethyl -oxopyrimidines (S-DACOs) as high active anti-HIV agents，Bio. Med. Chem. Lett.，2011，21（2）：694-697。

Patents

[1] Y.P. He, Y.T. Zheng, C. Li, et. al, The synthesis Methods and Application of 6-Cyclohexylmethyl Substituted S-DABO Analogues，ZL 200710066433.7, 2010.11.7

[2] Y.P. He，D.M. Zhuang, Q.Q. Cai, et. al, The synthesis Methods and Application of N-(4-(cyclohexylmethyl)-5-ethyl-6-oxo-1,6-dihydropyrimidin-2-yl)-2-phenylacetamide, ZL 201110163552.0, 2013.6.19

[3] Y.P. He，Xia Xue-Shan, Wu Dao-Chun, et. al,，The synthesis Methods and Application of 5-alkyl-6-(cyclohexylmethyl)-2-((2-hydroxy-2-phenylethyl)thio)-lpyrimidin-4(3H)-one，

ZL 201110358811.5, 2014.4.16

APPOINTMENTS & POSITIONS