Wen Chen

Wen Chen

Ph.D. 

Assistant Professor

Office: Chemistry Building 6F

Tel.: 86-(0)871-6531119/13116201168

Email: chenwenchem@163.com

Address: Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry of Education, Yunnan University, 2 North Cuihu Road, 650091 Kunming, P.R.China

Assistant Professor, Yunnan University (2015 - )

Ph.D., Yunnan University (2011.9 - 2014.12)

M.S., Yunnan Minzu University (2008.9 - 2011.7)

B.S., Yunnan Minzu University (2004.9 - 2008.7)

Research Interests

Total synthesis of natural products and pharmaceuticals

Foundation and Projects

Applied basic research projects of Yunnan Province 2016FD007 (2016 - 2019), responsible

Representative Publications

[1]  Wen Chen, Hongbin Zhang, Asymmetric construction of all-carbon quaternary stereocenters in the total synthesis of natural products, Science China Chemistry 2016, DOI: 10.1007/s11426-016-0055-0.

[2]  Wen Chen, Jian Ren, Minshou Wang, Lingjing Dang, Xianfu Shen, Xiaodong Yang Hongbin Zhang, Iodine mediated deprotection of N-tert-butanesulfinyl amines: a functional group compatible method, Chemical Communications 2014, 50, 6259-6262.

[3] Wen Chen, Xiao-Dong Yang, Yan Li, Li-Juan Yang, Xue-Quan Wang, Gao-Lan Zhang, Hong-Bin Zhang, Design, synthesis and cytotoxic activities of novel hybrid compounds between dihydrobenzofuran and imidazole, Organic & Biomolecular Chemistry 2011, 9, 4250-4255.

[4] Wen Chen, Xiao-Yan Deng, Yan Li, Li-Juan Yang, Wei-Chao Wan, Xue-Quan Wang, Hong-Bin Zhang, Xiao-Dong Yang, Synthesis and cytotoxic activities of novel hybrid 2-phenyl-3-alkylbenzofuran and imidazole/triazole compounds, Bioorganic & Medicinal Chemistry Letters 2013, 23, 4297-4302.

[5] Wen Chen, Li-Juan Yang, Shui-Xian Ma, Xiao-Dong Yang, Bao-Min Fan, Jun Lin, Crassicauline A/β-Cyclodextrin host–guest system: Preparation, characterization, inclusion mode, solubilization and stability, Carbohydrate Polymers, 2011, 84, 1321-1328.

[6] Wen Chen, Li-Juan Yang, Yan Li, Xue-Quan Wang, Shao-Jie Wang, Wei-Chao Wan, Hong-Bin Zhang, and Xiao-Dong Yang, Novel Tricyclic Indeno[5,6-b]furan -imidazole Hybrid Compounds: Design, Synthesis and Antitumor Activity, Letters in Drug Design & Discovery 2013, 10, 561-571.

[7] Wei-Chao Wan, Wen Chen, Lan-Xiang Liu, Yan Li, Li-Juan Yang, Xiao-Yan Deng, Hong-Bin Zhang, Xiao-Dong Yang, Synthesis and cytotoxic activity of novel hybrid compounds between 2-alkylbenzofuran and imidazole, Medicinal Chemistry Research 2014, 23, 1599-1611.(Wei-Chao Wan and Wen Chen contributed equally to this paper)

[8] Shui-Xian Ma, Wen Chen, Xiao-Dong Yang, Na Zhang, Shao-Jie Wang, Lin Liu, Li-Juan Yang, Alpinetin/hydroxypropyl-cyclodextrin host-guest system: Preparation, characterization, inclusion mode, solubilization and stability, Journal of Pharmaceutical and Biomedical Analysis, 2012, 67-68: 193-200.( Shui-Xian Ma and Wen Chen contributed equally to this paper)

[9] Li-Juan Yang, Wen Chen, Shui-Xian Ma, Yun-Tao Gao, Rong Huang, Sheng-Jiao Yan, Jun Lin. Host–Guest System of Taxifolin and Native Cyclodextrin or Its Derivative: Preparation, Characterization, Inclusion Mode, and Solubilization, Carbohydrate Polymers 2011, 85, 629-637.(The first author Li-Juan Yang was his master supervisor)

[10] Li-Juan Yang, Wen Chen, Yi-Ping Luo, Gan-Peng Li, Xiao-Dong Yang, Liang Li, Lignans and ketonic compounds from Litsea chinpingensis,Biochemical Systematics and Ecology 2009, 37, 696-698. (The first author Li-Juan Yang was his master supervisor)

Patents

[1] Xiao-dong Yang, Hong-bin Zhang, Wen Chen, Xue-quan Wang, Li-juan Yang, Liang Li, Indeno[5,6-b]furan-imidazole salts and their preparation, CN201210237387.3.

[2] Xiao-dong Yang, Hong-bin Zhang, Xue-quan Wang, Wen Chen, Liang Li, Jian-ping Liu, 2-Benzyl-benzofuran-imidazole salts and their preparation, CN201210237371.2, 2012.07.09, 2014.10.15.

APPOINTMENTS & POSITIONS

Invited reviewer of Chemical Biology & Drug Design